Eating the ER and the nucleus for survival under starvation conditions

Abstract

Recent studies have unveiled the vital role of autophagy in organelle degradation. Our new study in yeast revealed that autophagy targets the endoplasmic reticulum, and even the nucleus, under starvation conditions. Two landmark proteins that direct these organelles to autophagic degradation have been identified, allowing us to dissect the molecular mechanisms and physiological roles of these new pathways.