The insula of Reil in man and monkey. Architectonics, connectivity, and function

Abstract

Vorderster Anteil der Insel: piriform olfactory cortex = Allokortex, in Kontinuität mit lilmbischem Kortex. 3 Belts, von vorne nach hinten: (1) Agranular belt (periallocortical): Starke Verbindungen mit limbischem System, insb Amygdala, hinterem orbitofrontalem Kortex. Hauptsächlich Verb mit olfactory, amygdaloid, and paralimbic areas. Thalamische Verb: va VPMpc, DMmc ("connection between anterior insula and this nucleus may reflect topographic continuity of the anterior insula with orbitofrontal cortex"), CM-PF, midline ncli. Since it is so extensively interconnected with the amygdala, the anterior insula may also participate in the process of determining the affective tone of experience and behavior". (2) Intermediate belt (pro- or periisocortical) (3) Granular belt (isocortical): Verb mit höherem Assoziationskortex inkl dorsolat prefrontal lobes; Extensive somatosensory, auditory, motor, and association connections. Thalamische Verb: va VPI, Pulvinar. "Of all cortical regions studies thus far, ..insula has the most intense and widespread reciprocal connections with the amygdala." Insula as a major relay for conveying somatosensory information for limbic areas.