Adipokines and insulin resistance

669Citations
Citations of this article
453Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Obesity is associated with an array of health problems in adult and pediatric populations. Understanding the pathogenesis of obesity and its metabolic sequelae has advanced rapidly over the past decades. Adipose tissue represents an active endocrine organ that, in addition to regulating fat mass and nutrient homeostasis, releases a large number of bioactive mediators (adipokines) that signal to organs of metabolic importance including brain, liver, skeletal muscle, and the immune system - thereby modulating hemostasis, blood pressure, lipid and glucose metabolism, inflammation, and atherosclerosis. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones adiponectin, chemerin, leptin, omentin, resistin, retinol binding protein 4, tumor necrosis factor-α and interleukin-6, vaspin, and visfatin on insulin resistance.

References Powered by Scopus

Leptin and the regulation of body weight in mammals

4716Citations
N/AReaders
Get full text

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

4286Citations
N/AReaders
Get full text

The hormone resistin links obesity to diabetes

4198Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Adiponectin levels and risk of type 2 diabetes: A systematic review and meta-analysis

868Citations
N/AReaders
Get full text

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

798Citations
N/AReaders
Get full text

Molecular mechanisms of cancer development in obesity

723Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Rabe, K., Lehrke, M., Parhofer, K. G., & Broedl, U. C. (2008, November). Adipokines and insulin resistance. Molecular Medicine. https://doi.org/10.2119/2008-00058.Rabe

Readers over time

‘09‘10‘11‘12‘13‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘24‘25015304560

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 186

68%

Researcher 61

22%

Professor / Associate Prof. 14

5%

Lecturer / Post doc 13

5%

Readers' Discipline

Tooltip

Medicine and Dentistry 113

42%

Agricultural and Biological Sciences 99

37%

Biochemistry, Genetics and Molecular Bi... 41

15%

Sports and Recreations 15

6%

Save time finding and organizing research with Mendeley

Sign up for free
0