Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanyl-aminoethyl)thiophene) (PS-b-PIAT) nanoreactors are encapsulated together with free enzymes and substrates in a larger polybutadiene-b-poly(ethylene oxide) (PB-b-PEO) polymersome, forming a multicompartmentalized structure, which shows structural resemblance to the cell and its organelles. An original cofactor-dependent three-enzyme cascade reaction is performed, using either compatible or incompatible enzymes, which takes place across multiple compartments. Mimicking cells: Enzyme-filled polystyrene-b-poly(3-(isocyano-L-alanylaminoethyl) thiophene) (PS-b-PIAT) nanoreactors have been encapsulated together with free enzymes and substrates in a larger polymersome to form a multicompartmentalized structure, which shows structural resemblance to a cell and its organelles (see picture). An original cofactor-dependent three-enzyme cascade reaction, with either compatible or incompatible enzymes, takes place across multiple compartments. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
CITATION STYLE
Peters, R. J. R. W., Marguet, M., Marais, S., Fraaije, M. W., Van Hest, J. C. M., & Lecommandoux, S. (2014). Cascade reactions in multicompartmentalized polymersomes. Angewandte Chemie - International Edition, 53(1), 146–150. https://doi.org/10.1002/anie.201308141
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