Altered serotonin, dopamine and norepinepherine levels in 15q duplication and Angelman syndrome mouse models

38Citations
Citations of this article
94Readers
Mendeley users who have this article in their library.

Abstract

Childhood neurodevelopmental disorders like Angelman syndrome and autism may be the result of underlying defects in neuronal plasticity and ongoing problems with synaptic signaling. Some of these defects may be due to abnormal monoamine levels in different regions of the brain. Ube3a, a gene that causes Angelman syndrome (AS) when maternally deleted and is associated with autism when maternally duplicated has recently been shown to regulate monoamine synthesis in the Drosophila brain. Therefore, we examined monoamine levels in striatum, ventral midbrain, frontal cerebral cortex, cerebellar cortex and hippocampus in Ube3a deficient and Ube3a duplication animals. We found that serotonin (5HT), a monoamine affected in autism, was elevated in the striatum and cortex of AS mice. Dopamine levels were almost uniformly elevated compared to control littermates in the striatum, midbrain and frontal cortex regardless of genotype in Ube3a deficient and Ube3a duplication animals. In the duplication 15q autism mouse model, paternal but not maternal duplication animals showed a decrease in 5HT levels when compared to their wild type littermates, in accordance with previously published data. However, maternal duplication animals show no significant changes in 5HT levels throughout the brain. These abnormal monoamine levels could be responsible for many of the behavioral abnormalities observed in both AS and autism, but further investigation is required to determine if any of these changes are purely dependent on Ube3a levels in the brain. © 2012 Farook et al.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Farook, M. F., DeCuypere, M., Hyland, K., Takumi, T., LeDoux, M. S., & Reiter, L. T. (2012). Altered serotonin, dopamine and norepinepherine levels in 15q duplication and Angelman syndrome mouse models. PLoS ONE, 7(8). https://doi.org/10.1371/journal.pone.0043030

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 36

55%

Researcher 17

26%

Professor / Associate Prof. 10

15%

Lecturer / Post doc 3

5%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 23

37%

Biochemistry, Genetics and Molecular Bi... 14

23%

Neuroscience 13

21%

Medicine and Dentistry 12

19%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 10

Save time finding and organizing research with Mendeley

Sign up for free