Oxacalixarenes

Abstract

Oxacalix[n]arenes, or oxa[1n]metacyclophanes, have been known for almost half a century but have recently emerged to become an active area of investigation. The simplicity and modularity of modern methods to access diverse oxacalixarene systems, as well as the ability to tailor appended functional groups, makes the compounds ideal for applications-focused molecular design. This chapter details methods of oxacalixarene construction, post-cyclization derivatization of oxacalixarenes, and the diversity of applications that have been explored for this developing class of macrocycles.