Expression of Oestrogen Receptor α in the Brain of Brandt's Voles (Lasiopodomys brandtii): Sex Differences and Variations During Ovarian Cycles

Abstract

Oestrogen receptor (ER) α plays an important role in a variety of cognitive and behavioural functions. It has been shown that ERα expression in the brain is sexually dimorphic and is influenced by circulating oestrogen. In the present study, we mapped ERα-immunoreactive (-ir) cells in the forebrain of Brandt's voles (Lasiopodomys brandtii) to examine differences in ERα-ir expression between males and females and to reveal variations of ERα-ir expression during ovarian cycles in females. ERα-ir cells were found in many forebrain regions, including the lateral septum, bed nucleus of the stria terminalis, medial preoptic area (MPOA), anterior, arcuate and ventral medial (VMH) nuclei of the hypothalamus, as well as medial (MeA) and anterior cortical nuclei of the amygdala. Females had more ERα-ir cells in the VMH than males. Females during ovarian oestrus, but not di-oestrus or pro-oestrus, also had more ERα-ir cells in the MPOA than males. Furthermore, females in ovarian di-oestrus or oestrus had more ERα-ir cells in the MeA than males. Together, these data indicate that ERα expression in the brain of Brandt's voles is sexually dimorphic in specific brain areas. In addition, variations in the levels of circulating oestrogen during ovarian cycles can affect ERα expression in the female brain in a region-specific manner. © 2011 The Authors. Journal of Neuroendocrinology © 2011 Blackwell Publishing Ltd.