Genetics of familial amyotrophic lateral sclerosis

92Citations
Citations of this article
49Readers
Mendeley users who have this article in their library.

Abstract

Amyotrophic lateral sclerosis (ALS) is a late onset, rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. About 10% of all ALS cases are familial (FALS), and constitute a clinically and genetically heterogeneous entity. To date, FALS has been linked to mutations in 10 different genes and to four additional chromosomal loci. Research on FALS genetics, and in particular the discoveries of mutations in the SOD1, TARDBP, and FUS genes, has provided essential information toward the understanding of the pathogenesis of ALS in general. This review presents a tentative classification of all FALS-associated genes identified so far.

Figures

  • Table 1. Summary of the Genetic Causes of Familial ALS

Cited by Powered by Scopus

Get full text

This article is free to access.

236Citations
254Readers
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ticozzi, N., Tiloca, C., Morelli, C., Colombrita, C., Poletti, B., Doretti, … Silani, V. (2011). Genetics of familial amyotrophic lateral sclerosis. Archives Italiennes de Biologie, 149(1), 65–82. https://doi.org/10.5772/32498

Readers over time

‘17‘18‘19‘20‘21‘22‘23‘24036912

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 11

44%

Researcher 7

28%

Lecturer / Post doc 4

16%

Professor / Associate Prof. 3

12%

Readers' Discipline

Tooltip

Neuroscience 7

33%

Biochemistry, Genetics and Molecular Bi... 7

33%

Medicine and Dentistry 4

19%

Social Sciences 3

14%

Save time finding and organizing research with Mendeley

Sign up for free
0