H5N1-infected cells in lung with diffuse alveolar damage in exudative phase from a fatal case in Vietnam

37Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

Necropsied lung tissues of three fatal cases with avian influenza A virus (H5N1) infection in Vietnam were analyzed to detect H5N1 virus-infected cells. Formalin-fixed and paraffin-embedded lung tissue sections showed typical histological features of diffuse alveolar damage (DAD) in all cases. Immunohisto-chemistry for the influenza A virus nucleoprotein antigen revealed positive signals of bronchiolar and alveolar epithelial cells in only one patient, who exhibited DAD with an exudative phase and died on the 6th day after onset However, no signal was detected in the other two cases of DAD with a proliferative phase. These patients died on day 16 and day 17 after onset, respectively. H5N1 virus antigens were detected predominantly in epithelial cells in terminal bronchioles and in alveoli, i.e., type I and type II alveolar pneumocytes, and in alveolar macrophages. The pathogenesis of exudative DAD caused by H5N1 infection is discussed.

References Powered by Scopus

Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness

1247Citations
N/AReaders
Get full text

Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus

1245Citations
N/AReaders
Get full text

Influenza virus receptors in the human airway

1201Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2

609Citations
N/AReaders
Get full text

Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury

238Citations
N/AReaders
Get full text

Human infection with highly pathogenic avian influenza A (H5N1) virus: Review of clinical issues

126Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Liem, N. T., Nakajima, N., Phat, L. P., Sato, Y., Thach, H. N., Hung, P. V., … Suzuki, K. (2008). H5N1-infected cells in lung with diffuse alveolar damage in exudative phase from a fatal case in Vietnam. Japanese Journal of Infectious Diseases, 61(2), 157–160. https://doi.org/10.7883/yoken.jjid.2008.157

Readers over time

‘11‘12‘13‘14‘15‘16‘17‘19‘20‘21‘22‘2301234

Readers' Seniority

Tooltip

Researcher 7

58%

PhD / Post grad / Masters / Doc 3

25%

Professor / Associate Prof. 1

8%

Lecturer / Post doc 1

8%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 5

42%

Medicine and Dentistry 5

42%

Nursing and Health Professions 1

8%

Social Sciences 1

8%

Save time finding and organizing research with Mendeley

Sign up for free
0