N-functionalized benzimidazol-2-ylidene silver complexes: Synthesis, characterization, and antimicrobial studies

Abstract

2-Methoxyethyl, 2-diethylaminoethyl, and 2-phenylethyl-substituted N -heterocyclic carbene (NHC) precursors were treated with Ag2CO 3 to yield silver(I)-NHC complexes (1a-g) in dichloromethane as a solvent at room temperature. The 7 new silver-NHC complexes were fully characterized by means of 1H NMR, 13C NMR, and elemental analysis techniques. Using the agar dilution procedure recommended by the Laboratory and Clinical Standards Institute, the antimicrobial activities of all the silver-NHC complexes were studied against 2 gram-negative bacterial strains (Pseudomonas aeruginosa and Escherichia coli ), 2 gram-positive bacterial strains (Enterococcus faecalis and Staphylococcus aureus), and 2 fungi (Candida tropicalis and Candida albicans).© TÜBITAK.