Síndrome de boca ardiente

Abstract

The "Burning-Mouth-Syndrome" comprise "Glosodynia or Glosalgia" that means pain of the tongue. "Glosopyrosis": burning sensation." Dysesthesia or Paresthesia is a disconfortable experience inside the mouth. Glosodynia is used when the entire oral cavity is involved as well. The objective is to make a rewie about this syndrome and to postulate an hypothesis about etiology and diagnosis. Generally, about 80% of women suffer or once have suffered from Glosodynia. With a range of 40-81 years old, mean age 60 years old, correspond 2.9% male and 15.7% female. Llocalization: borders of tongue 46%, dorsum of tongue 46%, lips 50% and palate 46%. The etiology remains unknown. The hypothesis establish that this syndrome has a psychoneuroimmunoendocrinology background, relevant in the field of autoimmune diseases. The present review is centered in describing clinical, immumologic, endocrinologycal and neurologyc pathways involved in its genesis, and to focus its relationship with the role of noradrenalin and amyelinic fibers, the Beta receptors, histamine, bradiquinin, prostaglandins, HHS, CRF and ACTH, Il-1, IL-6, IL-8, IL-10, IL-2, TNFalpha, PAF, TGF-B, GHRH, PRL, glucocorticoids, mast cells, NK AP-1, local and systemic factors and an altered psychological base. Conclusions: Diagnosis could be made through the hypothalamic pituitary-adrenal axis activity by stress, investigating the cellular immune response. Under a serious underlying psychogenic disorder, patient must be referred to an appropriated specialist.