Noonan syndrome is a disease caused by aberrant signaling through the Ras GTPase, yet the underlying causal mutations remain unknown in many affected individuals. Two papers now identify gain-of-function mutations in the Ras nucleotide exchange factor SOS1 as a new player in this common developmental disorder. © 2006 Nature Publishing Group.
CITATION STYLE
Shannon, K., & Bollag, G. (2007, January). Sending out an SOS. Nature Genetics. https://doi.org/10.1038/ng0107-8
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