Exploration of PNA-peptide conjugates as potential antisense antibiotics necessitates a fast and efficient synthesis protocols for amounts that facilitate determination of structure-activity relationships and in vivo studies in animal infection models. Fmoc/Boc-protected PNA monomers are here used for assembly of oligomers by optimized protocols involving either a manual synthesis method at room temperature or automated microwave-assisted coupling of monomers on a peptide synthesizer.
CITATION STYLE
Shaikh, A. Y., Hansen, A. M., & Franzyk, H. (2020). Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis. In Methods in Molecular Biology (Vol. 2105, pp. 1–16). Humana Press Inc. https://doi.org/10.1007/978-1-0716-0243-0_1
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