Two mechanisms that account for major histocompatibility complex restriction of T cells

  • Kranz D
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Abstract

In recent studies, two distinct mechanisms have been proposed to account for major histocompatibility complex (MHC) restriction of T-cell activity: (a) evolution-driven interactions between T-cell receptor (TCR) variable regions and MHC, and (b) a requirement for CD4 or CD8 binding to MHC to initiate signalling through the TCR complex. Both mechanisms are likely to be essential, but for different reasons.

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Kranz, D. M. (2009). Two mechanisms that account for major histocompatibility complex restriction of T cells. F1000 Biology Reports, 1. https://doi.org/10.3410/b1-55

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