Fatty Acids and Lipid Paradox-Neuroprotective Biomarkers in Ischemic Stroke

8Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.

Abstract

Stroke is the primary cause of death and disability worldwide, with ischemic stroke up to 80% of the total cases. Lipid profile was established as a major risk factor for stroke, but recent studies show a paradoxical relationship between serum values and the outcome of stroke patients. Our study aims to analyze the impact of the classic extended lipid profile, including fatty acids as potential neuroprotective biomarkers for the outcome of ischemic stroke patients. We included 298 patients and collected clinical, paraclinical, and outcome parameters. We used a method consisting of high-performance liquid chromatography coupled with mass spectrometry to quantify serum fatty acids. We observed a negative correlation between National Institutes of Health Stroke Scale (NIHSS) at admission and total cholesterol (p = 0.040; r = −0.120), respectively triglycerides (p = 0.041; r = −0.122). The eicosapentaenoic to arachidonic acid ratio has a negative correlation, while the docosahexaenoic to eicosapentaenoic acid ratio positively correlates with all the prognostic parameters, showing a potential neuroprotective role for eicosapentaenoic acid in preventing severe ischemic stroke. The impact of the lipid profile paradox and the dependency relationship with the fatty acids represent a significant predictive factor for the functional and disability prognostic of ischemic stroke patients.

References Powered by Scopus

Classification of subtype of acute ischemic stroke definitions for use in a multicenter clinical trial

10288Citations
N/AReaders
Get full text

The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease

1920Citations
N/AReaders
Get full text

Stroke severity in atrial fibrillation: The Framingham study

1223Citations
N/AReaders
Get full text

Cited by Powered by Scopus

OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease in the Swedish Mammography Cohort

7Citations
N/AReaders
Get full text

Interplay of chronic obstructive pulmonary disease and colorectal cancer development: unravelling the mediating role of fatty acids through a comprehensive multi-omics analysis

6Citations
N/AReaders
Get full text

Glyceryl triacetate promotes blood–brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice

5Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Andone, S., Farczádi, L., Imre, S., & Bălașa, R. (2022). Fatty Acids and Lipid Paradox-Neuroprotective Biomarkers in Ischemic Stroke. International Journal of Molecular Sciences, 23(18). https://doi.org/10.3390/ijms231810810

Readers' Seniority

Tooltip

Researcher 2

50%

Lecturer / Post doc 1

25%

PhD / Post grad / Masters / Doc 1

25%

Readers' Discipline

Tooltip

Medicine and Dentistry 3

50%

Biochemistry, Genetics and Molecular Bi... 2

33%

Social Sciences 1

17%

Article Metrics

Tooltip
Mentions
Blog Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free