Electronically conductive and electrochemically active 3D-scaffolds based on electrospun poly(ethylene terephthalate) (PET) nano-fibers are reported. Vapour phase polymerization was employed to achieve an uniform and conformal coating of poly(3,4-ethylenedioxythiophene) doped with tosylate (PEDOT:tosylate) on the nano-fibers. The PEDOT coatings had a large impact on the wettability, turning the hydrophobic PET fibers super-hydrophilic. SH-SY5Y neuroblastoma cells were grown on the PEDOT coated fibers. The SH-SY5Y cells adhered well and showed healthy morphology. These electrically active scaffolds were used to induce Ca2+ signalling in SH-SY5Y neuroblastoma cells. PEDOT:tosylate coated nano-fibers represent a class of 3D host environments that combines excellent adhesion and proliferation for neuronal cells with the possibility to regulate their signalling. © 2009 Elsevier B.V. All rights reserved.
CITATION STYLE
Bolin, M. H., Svennersten, K., Wang, X., Chronakis, I. S., Richter-Dahlfors, A., Jager, E. W. H., & Berggren, M. (2009). Nano-fiber scaffold electrodes based on PEDOT for cell stimulation. Sensors and Actuators, B: Chemical, 142(2), 451–456. https://doi.org/10.1016/j.snb.2009.04.062
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