Characteristics of the renin-angiotensin-aldosterone system in carriers of polymorphic variants of the vdr gene with arterial hypertension and obesity

Abstract

Aim: To study the renin-angiotensin-aldosterone-system (RAAS) in patients with polymorphic variants of the Vitamin D receptor gene (VDR), arterial hypertension (AH) and obesity. Materials and methods. We included in this study 98 patients with stage II-III AH and obesity (33 men, 65 women, mean age 61. 1±9.9 years and BMI 43.3±5.0 kg/m2). The VDR gene study included genotypes TaqI, BsmI, Fokl. After identification of TaqI, BsmI, Fold VDR gene sites we carried out measurements of levels of RAAS markers. Results. We revealed an associative relationship between the presence of allele G of the BsmI site, C/C homozygosity of Fokl site of VDR gene and presence of AH in patients with obesity. An increase of renin level was noted only in the homozygous T/T genotype of Fokl, no differences in the concentration of aldosterone and angiotensin were detected between any of the studied genotypes. Conclusion. Polymorphic alleles and genotypes of the TOR gene can be used as predictors of AH development in obese patients with subsequent characterization of the state of the RAAS system.