Abstract
The novel biophysical model was updated to de-scribe the calcium (Ca2+) dynamics and contraction force in rat cardiac myocyte. The influence of calcium buffers and the mitochondrial sodium calcium exchanger (NCLX) in the exci-tation-contraction coupling were studied. Simulations showed that these mechanisms impact directly on the ryanodine recep-tors by influencing the Ca2+ release from the sarcoplasmic reticulum, altering the Ca2+ transient and, consequently, the contraction force in cardiac myocyte.
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da Silva, E. T. N. T., Silva, R. R., & Goroso, D. G. (2015). Computer simulations on the influence of NCLX and buffers calcium in rat cardiac myocyte. In IFMBE Proceedings (Vol. 49, pp. 854–857). Springer Verlag. https://doi.org/10.1007/978-3-319-13117-7_217
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