Susac Syndrome: an uncommon cause of impaired vision

N/ACitations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

A 35-year-old Caucasian woman presented an abrupt onset of bilateral impaired vision, and arrived to our attention two weeks later. She had a previous episode of mild dizziness. She underwent a fluorescein angiography showing branch retinal artery occlusions and a brain magnetic resonance imaging (MRI) revealing several supraand infratentorial FLAIR-hyperintense white matter lesions, two with contrast enhancement. Thrombophilic, autoimmune and infective (including Human Immunodeficiency Virus, Borrelia burgdorferi, Hepatitis B Virus, Hepatitis C Virus, Herpes Simplex Virus 1-2, Varicella Zoster Virus) screening was negative. Cerebrospinal fluid analysis showed intrathecal IgG synthesis. We suspected a Primary Central Nervous System Vasculitis, and intravenous steroids were started. Three months later a second brain MRI showed seven new lesions without contrast enhancement, and she revealed a cognitive impairment and bilateral hearing loss. Reviewing the clinical history and MRI, she fulfilled diagnostic criteria for Susac syndrome. She had two cycles of cyclophosphamide, and recovered in 6 months and then remained stable with metotrexate.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Barbero, P., Vecchio, D., Virgilio, E., Naldi, P., Comi, C., & Cantello, R. (2022). Susac Syndrome: an uncommon cause of impaired vision. Neurological Sciences, 43(6), 3919–3922. https://doi.org/10.1007/s10072-022-05865-8

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 1

50%

Researcher 1

50%

Readers' Discipline

Tooltip

Medicine and Dentistry 2

40%

Nursing and Health Professions 1

20%

Engineering 1

20%

Psychology 1

20%

Save time finding and organizing research with Mendeley

Sign up for free