Infection-associated gene expression-the pathogen perspective

Abstract

It is exciting to think that we now have data that link C. albicans gene expression responses to diverse environmental and genetic regulatory signals. We also have several technologies that allow precise measurement of RNA levels during infection. Together these capabilities allow us to infer many major signals that drive pathogen gene expression during infection. These signals and responses in turn yield insight into therapeutic targets for which inhibition may block infection. However, our deepening understanding of infection biology also reveals gaps in our understanding of how transcriptional networks may be revised during infection. That issue emphasizes the urgency of defining regulatory relationships in the infection environment.