Interaction of p190RhoGAP with C-terminal domain of p120-catenin modulates endothelial cytoskeleton and permeability

Abstract

Background: p120-catenin protein interactions regulate vascular permeability. Results: We identified p190RhoGAP-binding domain of p120-catenin and evaluated its functional significance. Conclusion: Binding of p190RhoGAP occurs at the amino acid 820-843 domain of p120-catenin and promotes activation of Rac and down-regulation of Rho signaling, leading to increased endothelial barrier. Significance: These data demonstrate functional significance of uncoupling the p120-catenin-p190RhoGAP interaction in the context of agonist-induced endothelial permeability. © 2013 by The American Society.