Secondary ion mass spectrometry is a technique used for surface analysis. The recent introduction of metal cluster ionization sources opened the possibility to probe biological tissues, due to its reduced in-source fragmentation. Despite its limitations in mass range of the molecules analyzed, a combination of minimal sample processing, sensibility, and unsurpassed lateral resolution makes TOF-SIMS a good tool for molecular imaging in pathology. © 2013 Springer Science+Business Media New York.
CITATION STYLE
Mas, S., Pérez, R., & Egido, J. (2013). Use of TOF-SIMS in vascular biology. Methods in Molecular Biology, 1000, 33–43. https://doi.org/10.1007/978-1-62703-405-0_3
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