Case report about fatal or near-fatal hypersensitivity reactions to cetuximab: Anticetuximab ige as a valuable screening test

Abstract

Hypersensitivity reactions are a classic side effect of cetuximab. We report the cases of three patients who developed life-threatening hypersensitivity to cetuximab, which could have been predicted by assessing the concentration of serum anticetuximab immunoglobulin (Ig)E. The anticetuximab IgE concentration could be an interesting test to predict which patients are at risk of experiencing severe hypersensitivity reactions to cetuximab. © The authors, publisher and licensee Libertas Academica Limited.