Many kinds of fibrosis are related to the content of pyridinoline cross-linking in type 1 collagen. In this study, ZIF-8 (zeolitic imidazolate framework), a metal organic framework (MOF), and ZIF8-hypocrellin B (ZIF8-HB), which combined the merits of hypocrellin B and the properties of ZIF-8, were prepared and applied to the photodegradation of the pyridinoline cross-linking. The effects of O2 and H2O2 in the photodynamic action were investigated. The results indicate that ZIF8-HB is an efficient photosensitizer to decompose pyridinoline cross-linking in collagen.
CITATION STYLE
Chen, Y., He, F., Liu, W., & Zhang, J. (2016). Spectroscopic studies on the interaction of pyridinoline cross-linking in type 1 collagen with ZIF8-HB. In Advances in Experimental Medicine and Biology (Vol. 923, pp. 63–67). Springer New York LLC. https://doi.org/10.1007/978-3-319-38810-6_9
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