New Biologically Active Compounds from the Nematode-Trappmg Fungus Arthrobotrys oligospora Fresen

Abstract

The isolation, structural elucidation and biological activities of oligosporon (1), oligosporol A (2) and oligosporol B (3), three new antibiotics from cultures of the predacious deuteromycete, Arthrobotrys oligospora, are reported. The structures were elucidated by means of high resolution mass and high field NMR spectroscopy. The compounds exhibited weak antimicrobial, cytotoxic and hemolytic effects, but were not active towards the nematode Caenorhabditis elegans. Other Arthrobotrys species were also found to produce these or similar compounds. © 1993, Walter de Gruyter. All rights reserved.