Antiinflammatory Principles of Atractylodes Rhizomes

Abstract

The crude drug “jutsu” prepared from Atractylodes rhizomes has been used for antiinflammatory purposes in Oriental medicine. In fact, a preparation from A. japonica was found to show significant inhibition of the increased vascular permeability induced by acetic acid. Fractionation of the extract, monitoring by bioassay, resulted in the isolation of two active principles, (+)-eudesma-4(14), 7(ll)-dien-8-one (VI) and atractylenolide I (VII). The structurally related principles atractylenolide II and III (VIII and IX) also had the tendency to show antiinflammatory activity. © 1979, IEEE. All rights reserved.