Preparation and in vitro evaluation of a multifunctional iron silicate@liposome nanohybrid for ph-sensitive doxorubicin delivery and photoacoustic imaging

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Abstract

For preventing premature drug release in neutral environment and avoiding them being trapped into the endosomal/lysosomal system, we developed a novel iron silicate@liposome hybrid (ILH) formulation, which can be used as a carrier to transport doxorubicin (DOX) in a pH-sensitive manner and to escape from endosomal/lysosomal trapping through "proton-sponge" effect. The high intensity of photoacoustic signal from in vitro photoacoustic imaging (PAI) experiments suggests that it is a promising candidate for PAI agent, providing the potential for simultaneously bioimaging and cancer-targeting drug delivery. Cytotoxicity of our formulation toward tumor cells was remarkably higher than free DOX (48.4±7.7% and 26.2±8.4%, P<0.001). Confocal laser scanning microscopy experiments showed the enhanced transportation and enrichment process of DOX in QSG-7703 cells. Taking together, we developed an easy approach to construct a multifunctional anticancer drug delivery/imaging system with a potency as a PAI agent. The strategy of combining drug carrier and imaging agent is an emerging platform for further construction of nanoparticle and may play a significant role in cancer therapy and diagnosis.

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Liu, Z., Tang, S., Xu, Z., Wang, Y., Zhu, X., Li, L. C., … Wang, X. (2015). Preparation and in vitro evaluation of a multifunctional iron silicate@liposome nanohybrid for ph-sensitive doxorubicin delivery and photoacoustic imaging. Journal of Nanomaterials, 2015. https://doi.org/10.1155/2015/541763

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