The identification of the mutation causing Huntington’s disease (HD) has led to the generation of a large number of mouse models. These models are used to further enhance our understanding of the mechanisms underlying the disease, as well as investigating and identifying therapeutic targets for this disorder. Here we review the transgenic, knock-in mice commonly used to model HD, as well those that have been generated to study specific disease mechanisms. We then provide a brief overview of the importance of standardizing the use of HD mice and describe brief protocols used for genotyping the mouse models used within the Bates Laboratory.
CITATION STYLE
Farshim, P. P., & Bates, G. P. (2018). Mouse models of Huntington’s disease. In Methods in Molecular Biology (Vol. 1780, pp. 97–120). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7825-0_6
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