Organocopper reagents for the synthesis of saturated,and α, β -ethylenic aldehydes and ketones

Abstract

Conjugate addition of organocopper reagents to α,β-ethylenic aldehydes is discussed. Use of α,β-ethylenic aminais is another approach to the same target, namely homologation of R-M to an aldehyde with three more carbon atoms. The α, β-ethy1 en ic aldehydes are easily prepared by carbocupration of α, β-acety1 en ic acetals. A new way to α,β-ethylen ic ketones, mediated by organo copper reagents is disclosed. © 1984 IUPAC