Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer

  • Dechaphunkul A
  • Phukaoloun M
  • Kanjanapradit K
  • et al.
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Abstract

Introduction . Despite advances in breast cancer systemic treatment, new prognostic and predictive factors are still needed. Tissue inhibitor of metalloproteinase-1 (TIMP-1), a physiologic inhibitor of matrix metalloproteinases (MMPs), can act in both pro- and antitumoral effects. As role of TIMP-1 in breast cancer is controversial, we aimed to determine the prognostic significance of TIMP-1 in breast cancer. Methods . A single center-based case-control study was applied. Primary breast cancers from women with early stage disease treated with standard adjuvant therapy were analyzed by gene expression microarrays and immunohistochemistry for TIMP-1. Results . At the optimized cut-point, patients with high TIMP-1 RNA levels had a significantly shorter time to relapse, with a hazard ratio (HR) of 1.64 ( P=0.04 ), but without significant differences in overall survival (HR 1.29, P=0.37 ). Although cytoplasmic overexpression of TIMP-1 protein was not correlated with early relapse (HR 1.0, P=0.92 ), there was a tendency for short overall survival in patients with high expression (HR 1.41, P=0.21 ). Conclusions . Our data indicate that elevated TIMP-1 RNA levels are independently prognostic for early recurrence, and there is a tendency for association of high cytoplasmic TIMP-1 protein levels with short survival in primary breast cancer.

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APA

Dechaphunkul, A., Phukaoloun, M., Kanjanapradit, K., Graham, K., Ghosh, S., Santos, C., & Mackey, J. R. (2012). Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer. International Journal of Breast Cancer, 2012, 1–10. https://doi.org/10.1155/2012/290854

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