Golgi neurons

Abstract

The Golgi cell is an essential cellular component of the cerebellar cortex and the only source of inhibition to the billions of granule cells forming the cortical input layer. Golgi cells are part of feed-forward, feedback and associative inhibitory circuits onto granule cells. Golgi cells are thus ideally placed to control the gain and temporal pattern of granule cell discharge in response to afferent mossy fi bers activity. Although several theoretical frames have been proposed, the impact of Golgi cell activity on the granular layer encoding capacity is still debated.