Leaky gut as a potential culprit for the paradoxical dysglycemic response to gastric bypass-associated ileal microbiota

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Abstract

Altered host-intestinal microbiota interactions are increasingly implicated in the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. We previously found, however, that RYGB-associated ileal microbiota can paradoxically impair host glycemic control when transferred to germ-free mice. Here we present complementary evidence suggesting that this could be due to the heightened development of systemic endotoxemia. Consistently, application of ileal content from RYGB-treated compared with sham-operated rats onto Caco-2 cell monolayers compromised barrier function and decreased expression of the barrier-stabilizing proteins claudin-4 and desmoglein-2. Our findings raise the possibility that RYGB-associated ileal microbiota produce and release sol-uble metabolites which locally increase intestinal permeability to promote systemic endotoxemia-induced insulin resistance, with potential implications for the treatment of RYGB patients who eventually relapse onto type 2 diabetes.

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Hankir, M. K., Seyfried, F., Schellinger, I. N., Schlegel, N., & Arora, T. (2021). Leaky gut as a potential culprit for the paradoxical dysglycemic response to gastric bypass-associated ileal microbiota. Metabolites, 11(3). https://doi.org/10.3390/metabo11030153

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