Clinical features of systemic lupus erythematosus

175Citations
Citations of this article
8Readers
Mendeley users who have this article in their library.
Get full text

Abstract

We compared the frequency of clinical features of systemic lupus erythematosus (SLE) and determined survival in 113 patients with younger‐onset lupus (age ⩾ < at clinical diagnosis) and 25 patients with older‐onset disease (age ⩾55 at diagnosis). The most striking difference was in the racial distribution; 59% of the younger patients were black, compared with only 20% of the older‐onset patients (P < 0.001). Major manifestations of lupus (including clinically evident renal disease, central nervous system involvement, cutaneous involvement, and hemocytopenia) occurred with similar frequency in both age groups. Antibodies to DNA were detectable equally often in both groups, but hypocomplementemia was more common in the younger patients. Five‐year survival in the younger‐onset group (79%) was similar to that of the older‐onset group (72%); there was a tendency toward relatively improved survival in patients in the latter group when compared with the expected survival of appropriately matched control populations. Major significant differences in racial distribution included 1) a higher incidence of serositis in older whites and in blacks regardless of age, and 2) more frequent hypocomplementemia in younger patients within both racial groups. Copyright © 1982 American College of Rheumatology

References Powered by Scopus

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

7190Citations
N/AReaders
Get full text

The natural history of systemic lupus erythematosus by prospective analysis<sup>1</sup>

840Citations
N/AReaders
Get full text

Determination of prognosis in chronic disease, illustrated by systemic lupus erythematosus

414Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation

2167Citations
N/AReaders
Get full text

Systemic lupus erythematosus: Clinical and immunologic patterns of disease expression in a cohort of 1,000 patients

962Citations
N/AReaders
Get full text

Predicting renal outcomes in severe lupus nephritis: Contributions of clinical and histologic data

372Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Ballou, S. P., Khan, M. A., & Kushner, I. (1982). Clinical features of systemic lupus erythematosus. Arthritis & Rheumatism, 25(1), 55–60. https://doi.org/10.1002/art.1780250109

Readers' Seniority

Tooltip

Professor / Associate Prof. 1

100%

Readers' Discipline

Tooltip

Medicine and Dentistry 2

50%

Agricultural and Biological Sciences 1

25%

Arts and Humanities 1

25%

Save time finding and organizing research with Mendeley

Sign up for free