Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes

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Abstract

Global genome nucleotide excision repair (GG-NER) eliminates a broad spectrum of DNA lesions from genomic DNA. Genomic DNA is tightly wrapped around histones creating a barrier for DNA repair proteins to access DNA lesions buried in nucleosomal DNA. The DNA-damage sensors XPC and DDB2 recognize DNA lesions in nucleosomal DNA and initiate repair. The emerging view is that a tight interplay between XPC and DDB2 is regulated by post-translational modifications on the damage sensors themselves as well as on chromatin containing DNA lesions. The choreography between XPC and DDB2, their interconnection with post-translational modifications such as ubiquitylation, SUMOylation, methylation, poly(ADP-ribos)ylation, acetylation, and the functional links with chromatin remodelling activities regulate not only the initial recognition of DNA lesions in nucleosomes, but also the downstream recruitment and necessary displacement of GG-NER factors as repair progresses. In this review, we highlight how nucleotide excision repair leaves a mark on chromatin to enable DNA damage detection in nucleosomes.

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APA

Apelt, K., Lans, H., Schärer, O. D., & Luijsterburg, M. S. (2021, December 1). Nucleotide excision repair leaves a mark on chromatin: DNA damage detection in nucleosomes. Cellular and Molecular Life Sciences. Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/s00018-021-03984-7

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