The role of intrahepatic γδ-T cells for liver injury induced by Salmonella infection in mouse

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Abstract

Liver injury was induced after infection with Salmonella choleraesuis 31N-1. In T-cell receptor-δ knockout mice, serum alanine transferase level was significantly decreased in comparison with normal control mice after Salmonella infection. On the contrary, in vivo administration of anti-γδ T- cell receptor monoclonal antibody (UC7-13D5) to stimulate γδ-T cells in infected mice significantly increased serum alanine transferase level but decreased bacterial growth compared with infected mice given control antibody (UC8; hamster IgG). These data suggest that γδ-T cells have effector activities not only for protection but also for liver injury during Salmonella infection.

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Ishigami, M., Nishimura, H., Yoshioka, K., Kakumu, S., & Yoshikai, Y. (1999). The role of intrahepatic γδ-T cells for liver injury induced by Salmonella infection in mouse. Microbiology and Immunology, 43(5), 461–469. https://doi.org/10.1111/j.1348-0421.1999.tb02429.x

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