Urinary β-2 microglobulin levels sensitively altered in an osteomalacia patient receiving add-on adefovir dipivoxil therapy for hepatitis B virus infection

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Abstract

Adefovir dipivoxil (ADV) is effective for hepatitis B virus (HBV) infection; however, ADV may provoke renal injury resulting in osteomalacia, and this side effect is seldom recognized until bone fractures emerge. We herein present a 66-year-old woman with HBV infection who received ADV for 6 years. Although she exhibited no sign of bone fractures, her urinary β-2 microglobulin (β2MG) level increased to 83,837 μg/L and scintigraphy revealed minimal fractures of the third rib. ADV was subsequently reduced and her urinary β2MG rapidly fell to 3,637 μg/L. Conversely, her urinary N-acetyl-β-D-glucosaminidase, and serum phosphate, alkaline phosphatase levels did not respond.

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Takagi, J., Morita, H., Ito, K., Ohashi, T., Hirase, S., Ito, T., … Yoneda, M. (2016). Urinary β-2 microglobulin levels sensitively altered in an osteomalacia patient receiving add-on adefovir dipivoxil therapy for hepatitis B virus infection. Internal Medicine, 55(12), 1599–1603. https://doi.org/10.2169/internalmedicine.55.6301

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