Neurotropic murine coronaviruses (MHV) provide an excellent animal model to study experimental modulation of the immune response to a vital pathogen with anti-idiotypic antibodies. It is known that among the various types of anti-idiotypic antibodies (anti-Id), those designated beta (β) or internal image can molecularly mimic the antigen and induce biological activities such as anti-viral protection and neutralization. We have recently shown that polyclonal non-internal image anti-idiotypic antibodies of the γ-type could induce protective anti-coronavirus immunity. In the present study, a polyclonal anti-Id (Ab2) was induced against a neutralizing murine monoclonal antibody (MAb1), designated 5B170.11. Mice immunized with this affinity- purified rabbit Ab2(α), a non-internal image antibody, were partially protected against lethal infection by the JHM strain of MHV. However, other polyclonal and monoclonal non-internal image Ab2 induced against another neutralizing MAb1, designated 4-11G.6, were not able to protect mice against lethal infection with the A59 strain of MHV. These results demonstrate that anti-viral protection by altering the idiotypic network with non-internal image-bearing anti-idiotype reagents can be achieved even with some anti-Id of the α-type.
CITATION STYLE
Yu, M., & Talbot, P. J. (1995). Induction of a protective immune response to murine coronavirus with non- internal image anti-idiotypic antibodies. In Advances in Experimental Medicine and Biology (Vol. 380, pp. 165–172). Springer New York LLC. https://doi.org/10.1007/978-1-4615-1899-0_27
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