Cytotoxic activity of some lupeol derivatives

11Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The synthesis of 3-O-acyl derivatives of lupeol is presented, as well as lupenone and the oxime of lupenone. The obtained derivatives were subjected to the MTT test in order to evaluate their cytotoxic activity toward HeLa, KB, MCF-7 and A-549 cell lines in comparison with lupeol (1). The IC50 values for lupeol (1) and all of the tested derivatives (2-6) were from about 7-10 μM for lupenone (5) to about 81 μM for o-phthaloyl-lupeol (4). Acylation of the C-3 hydroxy function of compound 1 decreased the cytotoxic activity of compounds 2-4. The most active anticancer agent was lupenone (5), with IC50 values 7.1-9.1 μM in comparison with 37.7-51.9 μM for lupeol (1).

Cite

CITATION STYLE

APA

Bednarczyk-Cwynar, B., Wiecaszek, T., & Ruszkowski, P. (2016). Cytotoxic activity of some lupeol derivatives. Natural Product Communications, 11(9), 1237–1238. https://doi.org/10.1177/1934578x1601100910

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free