ModRev - Model Revision Tool for Boolean Logical Models of Biological Regulatory Networks

Abstract

Biological regulatory networks can be represented by computational models, which allow the study and the analysis of biological behaviours, therefore providing a better understanding of a given biological process. However, as new information is acquired, biological models may need to be revised, in order to also account for this new information. Here, we present a model revision tool, capable of repairing inconsistent Boolean biological models. Moreover, the tool is able to confront the models, both with steady state observations, as well as time-series data, considering both synchronous and asynchronous update schemes. The tool was tested with a well-known biological model that was corrupted with different random changes. The presented tool was able to successfully repair the majority of the corrupted models.