A new route for the synthesis of 4-arylacetamido-2-aminothiazoles and their biological evaluation

Abstract

A series of 4-arylacetamido-2-amino- and 2-arylamino-1,3-thiazoles (4a-o) were synthesized in a single step in high yields from ?-bromoacetoacetanilides and thiourea/phenyl thioureas and were characterized by spectral and analytical methods. The compounds were evaluated for their in vitro antibacterial antifungal and antioxidant activities. In vitro antimicrobial evaluation of these compounds indicated their specificity towards Gram-positive species. p-Tolyl and m-chlorophenyl substituents on the arylamino moiety (compounds 4b and 4g) exhibited the lowest minimum inhibitory concentration values. The other compounds exhibited promising antimicrobial and moderate antioxidant activity.