Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity

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Abstract

IL-5 expresses various biologic effects on several types of lymphocytes, including B cells, eosinophils, and T cells. We demonstrated that the incubation of resting splenocytes from C57BL/6 mice in murine rIL-5 enhances IL-2 mediated lymphokine-activated killer (LAK) activity against various tumor cells. IL-5 alone, however, does not induce killer activity. IL-2-mediated LAK activity increases in proportion to the dose of IL-5. During the late phase of the culture period, IL-5 seems to have some effect on the induction of IL-2-mediated LAK activity. We expect that IL-5 will prove useful for adoptive immunotherapy.

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Aoki, T., Kikuchi, H., Miyatake, S., Oda, Y., Iwasaki, K., Yamasaki, T., … Honjo, T. (1989). Interleukin 5 enhances interleukin 2-mediated lymphokine-activated killer activity. Journal of Experimental Medicine, 170(2), 583–588. https://doi.org/10.1084/jem.170.2.583

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