Human genetics of coronary artery anomalies

Abstract

The genetics of human congenital coronary vascular anomalies (CCVAs) remains largely under-researched. This indeed is surprising, as coronary vascular defects represent a significant proportion of human congenital heart disease (CHD) and frequently are associated with malformation of different cardiac structures and diseases. In this brief chapter, we will attempt to summarize our current knowledge of the topic and propose a rationale for the development of novel approaches to the genetics of CCVAs.