The effect of androgen hormones in acne pathogenesis: A review

Abstract

At all ages (from birth to adulthood) large number of people may affect with acne, the disease with chronic inflammation of the pilosebaceous follicle. Although acne is a benign dermatological change, it has a massive effect and stays for a long time, with a defect in growth, self-confidence, and emotional stress. The interruption in observing the medical help aggravates the physical and psychological injuries; thus, it is related to elucidate the disease and to find the suitable treatment for it. In the skin, testosterone (T) and dihydrotestosterone (DHT) are synthesized and bind to the androgen receptor. Several revisions about acne sustenance the role of androgen hormones. There are two principles used for the treatment of acne rendering to the American Academy of Dermatology (ADD).