Anticoagulant activity of fucoidan from brown algae Fucus evanescens of the Okhotsk Sea

Abstract

In vitro and in vivo experiments showed that anticoagulant activity of sulfated polysaccharide from Fucus evanescens (brown algae of the Okhotsk Sea) was similar to that of heparin. Anticoagulant properties of fucoidan are determined by thrombin inhibition mediated via plasma antithrombin III. © 2003 Plenum Publishing Corporation.