AMP-activated protein kinase activation by 5-aminoimidazole-4-carbox-amide- 1-β-d-ribofuranoside (aicar) reduces lipoteichoic acid-induced lung inflammation

Abstract

Background: AMPK is a highly conserved energy homeostasis-regulating kinase. Results: Activation of AMPK by AICAR in vitro reduced cytokine production in alveolar macrophage cell line and in vivo reduced LTA-induced neutrophil influx, protein leak and cytokine/chemokine levels. Conclusion: AMPK activation inhibits LTA-induced lung inflammation in mice. Significance: AICAR reduces LTA inflammation. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.