Abstract
An efficient synthesis of novel dispirooxindoles has been achieved through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylideneimidazolidine-2,4-dione. The improved procedure features mild reaction conditions, high yields, high diastereoselectivities, a one-pot procedure and operational simplicity. © 1996-2013 MDPI AG (Basel, Switzerland).
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He, J., Ouyang, G., Yuan, Z., Tong, R., Shi, J., & Ouyang, L. (2013). A facile synthesis of functionalized dispirooxindole derivatives via a three-component 1,3-dipolar cycloaddition reaction. Molecules, 18(5), 5142–5154. https://doi.org/10.3390/molecules18055142
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