Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results in severe obesity and a variety of endocrine abnormalities in animals and humans. Several studies indicated that leptin plays an important role in immune responses. It exerts protective anti-inflammatory effects in models of acute inflammation and during activation of innate immune responses. In contrast, leptin stimulates T lymphocyte responses, thus having rather a proinflammatory role in experimental models of autoimmune diseases. Clinical studies have so far yielded inconsistent results, suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans. © 2006 BioMed Central Ltd.
CITATION STYLE
Bernotiene, E., Palmer, G., & Gabay, C. (2006, October). The role of leptin in innate and adaptive immune responses. Arthritis Research and Therapy. https://doi.org/10.1186/ar2004
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