Abstract
The gyrA and parC genes of 31 clinical isolates of Enterococcus faecalis, including fluoroquinolone-resistant isolates, were partially sequenced and analyzed for target alterations. Topoisomerase IV may be a primary target in E. faecalis, but high-level fluoroquinolone resistance was associated with simultaneous alterations in both GyrA and ParC.
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CITATION STYLE
Kanematsu, E., Deguchi, T., Yasuda, M., Kawamura, T., Nishino, Y., & Kawada, Y. (1998). Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis. Antimicrobial Agents and Chemotherapy, 42(2), 433–435. https://doi.org/10.1128/aac.42.2.433
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