Effects of clopidogrel and prednisone on platelet function in healthy dogs

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Abstract

Background: Glucocorticoids cause hypercoagulability, but it is unknown if they counteract clopidogrel's antiplatelet effects. Hypothesis/Objectives: Determine the effects of clopidogrel and prednisone on platelet function. Animals: Twenty-four healthy dogs. Methods: Double-blinded, placebo-controlled randomized trial. Platelet function was evaluated using a platelet function analyzer and impedance aggregometry (days 0, 14, and 28) for dogs treated with placebo, clopidogrel (2-3 mg/kg/d), prednisone (2 mg/kg/d), or prednisone with clopidogrel PO for 28 days. Results were categorized as nonresponder versus responder (platelet function analyzer), and inadequate, ideal, or excessive response (aggregometry). Results were compared using mixed model, split-plot repeated measures analysis of variance and generalized estimating equation proportional odds models. P

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Thomason, J., Mooney, A. P., Price, J. M., & Whittemore, J. C. (2020). Effects of clopidogrel and prednisone on platelet function in healthy dogs. Journal of Veterinary Internal Medicine, 34(3), 1198–1205. https://doi.org/10.1111/jvim.15759

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