Engineered Nanomaterials and Type I Allergic Hypersensitivity Reactions

39Citations
Citations of this article
80Readers
Mendeley users who have this article in their library.

Abstract

Type I allergic hypersensitivity disorders (atopy) including asthma, atopic dermatitis, allergic rhinitis, and food allergy are on the rise in developed and developing countries. Engineered nanomaterials (ENMs) span a large spectrum of material compositions including carbonic, metals, polymers, lipid-based, proteins, and peptides and are being utilized in a wide range of industries including healthcare and pharmaceuticals, electronics, construction, and food industry, and yet, regulations for the use of ENMs in consumer products are largely lacking. Prior evidence has demonstrated the potential of ENMs to induce and/or aggravate type I allergic hypersensitivity responses. Furthermore, previous studies have shown that ENMs could directly interact with and activate key T-helper 2 (Th2) effector cell types (such as mast cells) and the complement system, which could result in pseudoallergic (non-IgE-mediated) hypersensitivity reactions. Nevertheless, the underlying molecular mechanisms of ENM-mediated induction and/or exacerbation of type I immune responses are poorly understood. In this review, we first highlight key examples of studies that have demonstrated inherent immunomodulatory properties of ENMs in the context of type I allergic hypersensitivity reactions, and most importantly, we attempt to put together the potential molecular mechanisms that could drive ENM-mediated stimulation and/or aggravation of type I allergic hypersensitivity responses.

References Powered by Scopus

Toxic potential of materials at the nanolevel

8251Citations
N/AReaders
Get full text

Understanding biophysicochemical interactions at the nano-bio interface

6177Citations
N/AReaders
Get full text

Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications

1646Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Hard Nanomaterials in Time of Viral Pandemics

80Citations
N/AReaders
Get full text

Understanding the Role and Impact of Poly (Ethylene Glycol) (PEG) on Nanoparticle Formulation: Implications for COVID-19 Vaccines

64Citations
N/AReaders
Get full text

Advances in carbon nanomaterials for immunotherapy

29Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Alsaleh, N. B., & Brown, J. M. (2020, February 14). Engineered Nanomaterials and Type I Allergic Hypersensitivity Reactions. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2020.00222

Readers over time

‘20‘21‘22‘23‘24‘2507142128

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 17

63%

Researcher 6

22%

Professor / Associate Prof. 2

7%

Lecturer / Post doc 2

7%

Readers' Discipline

Tooltip

Medicine and Dentistry 11

39%

Agricultural and Biological Sciences 6

21%

Biochemistry, Genetics and Molecular Bi... 6

21%

Immunology and Microbiology 5

18%

Article Metrics

Tooltip
Social Media
Shares, Likes & Comments: 21

Save time finding and organizing research with Mendeley

Sign up for free
0